Author archives: creativepeptides

Cell-Penetrating Peptides: Features, Mechanisms, Applications


Cell-penetrating peptides (CPPs) refer to water-soluble, partly hydrophobic, and/or polybasic short peptides that are fewer than 30 amino acids in size. Different types of CPPs like chimeric peptides and hydrophobic peptides have different lengths, charges, solubility, and hydrophobicity. At current, cell-penetrating peptides are often classified in line with their characteristics, including origin, conformation, and ...

Continue reading

Four Well-Established Strategies Used in Hit Identification


The major preclinical phases of peptide drug discovery encompass initial target identification and validation, hit identification, high throughput screening, lead optimization, etc. Among them, hit identification is one of the most critical steps in identifying peptides that can interact with well-validated targets.

 

Hit identification (HI) follows the process of target validation, in which the compound ...

Continue reading

Total Peptide Library: More Flexible and Productive


Peptides with low molecular weight have been known to be less allergenic and the diverse physiological roles of peptides make them suitable candidates for the development of therapeutic agents. Peptide drugs are widely used in the prevention, diagnosis, and treatment of diseases such as cancer, diabetes, and AIDS. However, the development of peptide drugs is ...

Continue reading

Useful Approaches for Labeling Peptides with Fluorescent Dyes


Due to the high sensitivity, flexibility, selectivity, and environmental stability, fluorescent techniques are broadly applied in biological research. Peptides provide unique possibilities for the development of efficient and selective fluorescent sensors because of their modular nature, synthetic accessibility, and biomolecular recognition potential. Accordingly, labeling peptides with fluorescent dyes become a powerful tool for studying biologically ...

Continue reading