Author archives: bocsciences

Peptides Labeling with Stable Isotope


Peptides are organic compounds formed by the dehydration of amino acids and intermediate products of protein hydrolysis. Peptides have strong biological activity, which can regulate the functional activities of cells in living organisms, and play a variety of roles in medicine, cosmetics, food, and other fields. With the more and more extensive and in-depth applications ...

Continue reading

Antibody-drug Conjugates Manufacturing and Future Focus


Antibody-drug conjugates (ADCs) are formed by covalent biochemical conjugation of monoclonal antibodies (mAb) with payload drugs through small molecular linkers. They are regarded as an emerging class of drugs designed for high-specificity targeting and destruction of cancer cells, since the specificity of mAb to tumor cells allows small-molecule drugs to target tumor tissues, effectively reducing ...

Continue reading

PROTAC-based Methods as Traditional PROTAC Protein Degradation Technology Alternatives


In recent years, the transition from inhibition of aberrant protein function to specific degradation of desired proteins with Proteolysis Targeting Chimeras (PROTACs) has resulted in remarkable progress and is currently affecting a paradigm shift in drug discovery and therapy development. PROTAC approach has allowed quick expansion of the “druggable proteome” beyond proteins that bear distinct ...

Continue reading