Expression system refers to the system that synthesizes recombinant proteins through specific cells and transfected DNA vectors, which can translate the supplied DNA genetic information into the amino acid sequence specific to the target protein. After translation, these molecules are affected by post-translational modification (PTM). There are significant differences in the frequency and complexity of ...
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Therapeutic Protein Expression System
PROTAC-based Methods as Traditional PROTAC Protein Degradation Technology Alternatives
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In recent years, the transition from inhibition of aberrant protein function to specific degradation of desired proteins with Proteolysis Targeting Chimeras (PROTACs) has resulted in remarkable progress and is currently affecting a paradigm shift in drug discovery and therapy development. PROTAC approach has allowed quick expansion of the “druggable proteome” beyond proteins that bear distinct ...